Dr. Brunicardi’s areas of specialty include gastroenterology, pancreas cancer, breast cancer, and minimally invasive surgery.

Publications

A prolific writer, Dr. Brunicardi has co-authored 154 publications, 21 chapters, and 101 abstracts. He serves as Editor-in-Chief of Schwartz’s Principles of Surgery textbook. Dr. Brunicardi also serves as a reviewer for such publications as Annals of Surgery, Diabetes, Pancreas, Journal of Surgical Research, Surgery, and American Journal of Physiology. He has also served as a reviewer for the National Institutes of Diabetes and Digestive and Kidney Diseases, part of the National Institutes of Health. A widely sought speaker, Dr. Brunicardi has taken part in more than 244 lectures regarding his clinical interests.

 Glenn R. Cunningham, M.D.

Professor of Medicine and Molecular & Cellular BiologyEducation
M.D.: University of Oklahoma Medical School, 1966
Residency:
1966-1967 Straight Medical Internship, Duke University Medical Center
1967-1968 Junior Assistant Residency (Medicine), Duke University Medical Center
1968-1970 Endocrinology Fellowship, Duke University Medical Center
1970-1971 Chief Resident in Medicine, VA Hospital, Durham, North Carolina

Research Interests
Androgen deficiency
Prostate cancer
Benign prostatic hyperplasia
Diabetes
Recent Publications
Shao TC, Li H, BS; Ittmann M, Cunningham GR. Effects of Dutasteride on Prostate Growth in the Large Probasin-Large T Antigen Mouse Model of Prostate Cancer. J Urol. 2007;178:1521-7.

Tung DS, Cunningham GR. Androgen Deficiency in Men. The Endocrinologist 2007;17:101–115.

Sanjay N. Mediwala, MD and Glenn R. Cunningham, MD. Endocrine Evaluation of Male Sexual Function. In: Textbook of Erectile Dysfunction. Edited by Culley Carson, Roger Kirby, Irwin Goldstein. In Press.

Cunningham GR. Late-Onset Hypogonadism. Medscape. In Press

Shao TC, Li H, Kasper S, Matusik R, Ittmann M, Cunningham GR. Comparison of the Growth-Promoting Effects of Testosterone and 7-|*alpha*|-Methyl-19-Nor-Testosterone (MENT) on the Prostate and Levator Ani Muscle of LPB-Tag Transgenic Mice. Prostate. 2006;66:369-76.

Garcia JM, Epner D, Hayes T, Mann D, Li H, Marcelli M, Cunningham GR. Hypogonadism in male patients with cancer. Cancer. 2006;106:2583-91.

Bhasin S, Cunningham GR, Hayes F, Matsumoto AM, Snyder PJ, Swerdloff RS, Montori VM. Testosterone therapy in adult men with androgen deficiency syndromes: an endocrine society clinical practice guideline.. J Clin Endocrinol Metab, 2006;91:1995-2010.

Marcelli M, Cunningham GR, Garcia JM, Lo KC, Lamb DJ. Chapter 45. Molecular Endocrinology of the Testis. In: Principles of Molecular Medicine. 2nd Edition. Eds: Runge MS, Patterson C., Humana Press, Totowa, NJ, 2006.

Cunningham GR. Testosterone replacement therapy for late-onset hypogonadism. Nat Clin Prac Urol. 2006;3:260-7.
 
Schenk E, Tung DS, Soodini G, Cunningham GR. Diagnosis and Management of Hyperthyroidism. Emergency Medicine 2006;38:21-38.
 
Hijazi R, Cunningham GR. Andropause in Human Aging. P. Michael Conn, editor. In: Handbook of Models for Human Aging. Elsevier/Academic Press, San Diego, CA, 2006, Chapter 63, pp. 749-758.

Garcia JM, Garcia-Touza M, Hijazi R, Taffet G, Epner D, Mann D, Smith RG, Cunningham GR, Marcelli M. Active Ghrelin Levels And Active/Total Ghrelin Ratio In Cancer-Induced Cachexia. J Clin Endocrinol Metab. 2005;90:2920-6.

13. Hijazi RA, Cunningham GR. Andropause: Is Androgen Replacement Therapy Indicated for the Aging Male. Annu Rev Med. 2005;56:117-37.

14. Crumpler CD, Hijazi R, Cunningham GR. Male Sexual Dysfunction: An Individualized Approach. Emergency Medicine 2005;37:9-18.

 Dr. Hashem El-Serag
Professor of Medicine
 Chief Gastroenterology & Hepatology
 Baylor College of Medicine
 GI Section Chief, Michael E. DeBakey VA Medical Center.

Aging of the Hepatitis C Virus-Infected Persons in the United States: A Multiple Cohort Model of HCV Prevalence and Disease Progression.

Davis GL, Alter MJ, El-Serag H, Poynard T, Jennings LW.

 

Gastroenterology. 2009 Oct 24. [Epub ahead of print]PMID: 19861128

 

Irritable bowel syndrome symptoms and health related quality of life in female veterans.

Graham DP, Savas L, White D, El-Serag R, Laday-Smith S, Tan G, El-Serag HB.

 

Aliment Pharmacol Ther. 2009 Oct 8. [Epub ahead of print] No abstract available. PMID: 19814746

 

Statin Therapy and Serum Transaminases Among a Cohort of HCV-Infected Veterans.

Henderson LM, Patel S, Giordano TP, Green L, El-Serag HB.

Dig Dis Sci. 2009 Sep 3. [Epub ahead of print]PMID: 19731022

 

Surveillance in Barrett's esophagus: lessons from behavioral economics.

El-Serag HB, Naik AD.

 

Gastroenterology. 2009 Sep;137(3):763-5. Epub 2009 Jul 28. No abstract available. PMID: 19643189

 

Diagnostic yield of oesophagogastroduodenoscopy in children with abdominal pain.

Thakkar K, Chen L, Tatevian N, Shulman RJ, McDuffie A, Tsou M, Gilger MA, El-Serag HB.

 

Aliment Pharmacol Ther. 2009 Sep 15;30(6):662-9. Epub 2009 Jul 2.PMID: 19573168

The extent and determinants of prescribing and adherence with acid-reducing medications: a national claims database study.l-Serag HB, Fitzgerald S, Richardson P.

Am J Gastroenterol. 2009 Sep;104(9):2161-7. Epub 2009 Jun 30.PMID: 19568229

 

The big burden of obesity.

Nguyen DM, El-Serag HB.

Gastrointest Endosc. 2009 Oct;70(4):752-7. Epub 2009 Jun 25. No abstract available. PMID: 19559415

 

Missed opportunities to initiate endoscopic evaluation for colorectal cancer diagnosis.

Singh H, Daci K, Petersen LA, Collins C, Petersen NJ, Shethia A, El-Serag HB.

Am J Gastroenterol. 2009 Oct;104(10):2543-54. Epub 2009 Jun 23.PMID: 19550418

 

Medication Usage and the Risk of Neoplasia in Patients With Barrett's Esophagus.

Nguyen DM, El-Serag HB, Henderson L, Stein D, Bhattacharyya A, Sampliner RE.

Clin Gastroenterol Hepatol. 2009 Jun 10.

 

The utility of evaluating low serum albumin gradient ascites in patients with cirrhosis.

Khandwalla HE, Fasakin Y, El-Serag HB.

Am J Gastroenterol. 2009 Jun;104

 

Distribution and manifestations of inflammatory bowel disease in Asians, Hispanics, and African Americans: a systematic review.

Hou JK, El-Serag H, Thirumurthi S.

Am J Gastroenterol. 2009 Aug;

 

Gene expression in Barrett's esophagus: laser capture versus whole tissue.

El-Serag HB, Nurgalieva ZZ, Mistretta TA, Finegold MJ, Souza R, Hilsenbeck S, Shaw C, Darlington G.Scand J Gastroenterol. 2009

 

Statins and the risk of colorectal carcinoma: a nested case-control study in veterans with diabetes. Hachem C, Morgan R, Johnson M, Kuebeler M, El-Serag H.

Am J Gastroenterol. 2009 May;104

 

Epidemiology, screening, diagnosis and treatment of hepatocellular carcinoma.

Hussain K, El-Serag HB. Minerva Gastroenterol Dietol. 2009 Jun;55

 

Using a multifaceted approach to improve the follow-up of positive fecal occult blood test results. Singh H, Kadiyala H, Bhagwath G, Shethia A, El-Serag H, Walder A, Velez ME, Petersen LA. Am J Gastroenterol. 2009 Apr;104

 

Alcohol drinking and the risk of Barrett's esophagus and esophageal adenocarcinoma.

El-Serag HB, Lagergren J.Gastroenterology. 2009 Apr;136

 

Phase I and II enzyme polymorphisms as risk factors for Barrett's esophagus and esophageal adenocarcinoma: a systematic review and meta-analysis. Bull LM, White DL, Bray M, Nurgalieva Z, El-Serag HB. Dis Esophagus. 2009;22

 

Systematic review: the global incidence and prevalence of peptic ulcer disease.

Sung JJ, Kuipers EJ, El-Serag HB.Aliment Pharmacol Ther. 2009 May 1;29

 

Statins are associated with a reduced risk of hepatocellular carcinoma in a large cohort of patients with diabetes. El-Serag HB, Johnson ML, Hachem C, Morgana RO.

Gastroenterology. 2009 May;136

 

Risk of hepatobiliary and pancreatic cancers after hepatitis C virus infection: A population-based study of U.S. veterans. El-Serag HB, Engels EA, Landgren O, Chiao E, Henderson L, Amaratunge HC, Giordano TP. Hepatology. 2009 Jan;49

 

Hepatocellular cancer care: cost is important but only one factor of disease burden.

Kanwal F, El-Serag HB.J Hepatol. 2009 Jan;50

    

 

Dr. Xin-Hua Feng

Professor of Surgery, and of Molecular & Cellular Biology

Baylor College of Medicine

A. Education

1983             B.S., Biology, Wuhan University, Wuhan, China

1986             M.S., Genetics, Institute of Genetics and The Graduate University of Chinese Academy of Sciences, China

1992             Ph.D., Botany, University of Maryland at College Park (UMCP)

1993-1997    Postdoctoral fellow, Biochemistry/Cell Biology, University of California-San Francisco (UCSF)

B. POSITIONS AND HONORS

EMPLOYMENT

7/1997-9/1999       Assistant Cell Biologist (Research track faculty), Dept of Growth and Development, UCSF

10/1999-6/2003     Assistant Professor, Depts of Molecular & Cellular Biology, and Surgery, BCM

6/2003-10/2007     Associate Professor (tenured), Depts of Molecular & Cellular Biology and Surgery, BCM

2002-present         Member, Dan L. Duncan Cancer Center, BCM

2002-present         Member, Biology of Inflammation Center, BCM

2006-present         Member, George M. O’Brien Kidney Research Center, BCM

2006-present         Member, Stem Cells and Regenerative Medicine Center (STaR), BCM

11/2007-present    Professor (tenured), Depts of Molecular & Cellular Biology, and Surgery, BCM

 

HONORS/AWARDS

American Cancer Society Postdoctoral Fellowship, 1995-1998

Research Achievement Award, W.M. Keck Fndn Distinguished Young Scholars in Medical Research, 2001

American Cancer Society Research Scholar, 2003-2007

The Leukemia & Lymphoma Society Scholar, 2003-2008

Distinguished Oversea Young Scholar, National Natural Science Foundation of China, 2004

The Michael E. DeBakey Research in Excellence Award, BCM (College-wide), 2006

MCB Research in Excellence Award, BCM Department of Molecular & Cellular Biology, 2007

Editorial Board, Journal of Biological Chemistry (JBC), 2006-2011

Associate Editor, BMC Developmental Biology, 2009-2012

Associate Editor, Journal of Genetics and Genomics, 2009-present

C. RESEARCH INTERESTS

Dr. Feng’s research focuses on understanding the fundamental process for how human diseases develop.  Dr. Feng’s research also involves in the development of novel genetic medicine for cancer, vascular diseases, inflammation and viral infections.

D. SELECTED PUBLICATIONS

Dr. Feng has contributed more than 70 research articles to scholarly and professional journals, and made presentations nationally and internationally on a range of topics related to the growth of normal and cancer cells.

Derynck R, Zhang Y, Feng X-H. (1998) Smads: transcriptional activators of TGF-b responses.  Cell 95: 737-740.  PMID: 9865691

Dong C, Li Z, Alvarez R Jr, Feng X-H, Goldschmidt-Clermont P. (2000) Microtubule binding to Smads may regulate TGF-b activity.  Mol Cell 5: 1-20.  PMID: 10678166

Feng X-H, Lin X, Derynck R. (2000) Smad2, 3, 4 and Sp1 cooperate to induce transcription of cyclin-dependent kinase inhibitor p15Ink4B in response to TGF-b.  EMBO J 19: 5178-5193.  PMID: 11013220; PMC302105

Lin X, Liang M, Feng X-H. (2000) Smurf2 as a ubiquitin E3 ligase for proteasome-dependent degradation of Smad2 in TGF-b signaling.  J Biol Chem 275: 36818-36822.  PMID: 11016919

Feng X-H, Liang Y-Y, Liang M, Zhai W, Lin X. (2002). Direct interaction of c-Myc with Smad2 and Smad3 to inhibit TGF-b-mediated induction of the CDK inhibitor p15Ink4B.  Mol Cell 9: 133-143.  PMID: 11804592

Lin X, Liang M, Liang Y-Y Brunicardi FC, Melchior F, Feng X-H. (2003). Activation of TGF-b signaling by SUMO modification of tumor suppressor Smad4/DPC4. J Biol Chem 278: 18714-18719.  PMID: 12621041

Lin X, Liang Y-Y, Sun B, Liang M, Brunicardi FC, Feng X-H. (2003). Smad6 recruits transcription corepressor CtBP to repress BMP-induced transcription.  Mol Cell Biol 23: 9081-9093.  PMID: 14645520; PMC309600

Lin X, Sun B, Liang M, Liang Y, Gast A, Hildebrand J, Brunicardi F, Melchior F, Feng X-H. (2003). Opposed regulation of CtBP function by SUMOylation and PDZ binding.  Mol Cell 11: 1389-1396.  PMID: 12769861

Li GQ, Wang D, Feng X-H, Wang X-J. (2004). Latent TGF-b 1 overexpression in keratinocytes results in a severe psoriasis-like skin disorder.  EMBO J 23: 1770-1781.  PMID: 15057277; PMC394237

Miura M, Chen X-D, Gronthos S, Bi Y, Allen MR, Lakhani S, Flavell RA, Feng X-H, Robey PG, Young M, Shi S. (2004) Caspase-3 inhibitor (Z-DMVD-FMK) accelerates osteoporossis in overiectomized mice by increasing apoptosis of bone marrow stromal stem cells. J Clin Invest 114: 1704-1713.  PMID: 15599395; PMC535063

Liang M, Liang Y-Y, Wrighton K, Ungermannova D, Wang X, Brunicardi FC, Liu X, *Feng X-H, Lin X. (2004).  Ubiquitination and proteolysis of cancer-derived Smad4 mutants by SCF^Skp2. Mol Cell Biol 24: 7524-7537. (*co-corresponding author)  PMID: 15314162; PMC506984

Feng X-H, Derynck R. (2005). Specificity and versatility of TGF-b signaling through Smads.  Ann Rev Cell Dev Biol 12: 659-693.  PMID: 16212511

Lin X, Duan X, Liang Y-Y, Su Y, Wrighton K, Hu M, Long J, Davis C, Wang J, Brunicardi FC, Shi Y, Chen Y-G, Meng A, Feng X-H. (2006). PPM1A functions a Smad phosphatase to terminate TGF-b signaling.  Cell, 125: 915-928.  PMID: 16751101 (featured in Cell [125: 838-840] and ACS Chem Biol [1: 346-348])

Wrighton, K, Willis D, Long J, Liu F, Lin X, Feng X-H. (2006). Small carboxy-terminal domain phosphatases dephosphorylate the regulatory linker regions of Smad2 and Smad3 to enhance TGF-b signaling.  J Biol Chem 281: 38365–38375.  PMID: 17035229

Ishinaga H, Jono H, Lim JH, Kweon S-M, Xu H, Ha U, Xu H, Feng X-H, Chen L, Li J-D. (2007) TGF-b induces p65 acetylation to enhance bacteria-induced NF-kB activation.  EMBO J 26: 1150-1162.  PMID: 17268554; PMC1852843

Lim JH, Stirling B, Derry J, Koga T, Jono H, Woo CH, Xu H, Bourne P, Ha UH, Ishinaga H, Xu H, Andalibi A, Feng X-H, Zhu H, Huang Y, Zhang W, Weng X, Yan C, Yin Z, Briles DE, Davis RJ, Flavell RA, Li JD. (2007). Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections.  Immunity 27: 349-360.  PMID: 17723219

Dai, F, Chang C, Lin X, Dai G, Mei L, Feng X-H. (2007). Erbin inhibits TGF-b signaling through a novel Smad-interacting domain.  Mol Cell Biol 27: 6183-6194.  PMID: 17591701; PMC1952163

Wang D, Long J, Dai F, Liang M, Feng X-H, Lin X. (2008). Bcl6 represses Smad signaling in TGF-b resistance. Cancer Res 68: 783-789.  PMID: 18245479

Yang XO, Nurieva R, Martinez GJ, Kang HS, Chung Y, Pappu BP, Shah B, Chang SH, Schluns KS, Watowich SS, Feng X-H, Jetten AM, and Dong C. (2008). Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity, 29:44-56. PMID: 18585065

Wrighton K, Dai F, Feng X-H. (2008). A new kid on the TGFb block: TAZ controls Smad nucleocytoplasmic shuttling. Dev Cell 15: 8-10. PMID 18606136

Wrighton K, Lin X, Feng X-H. (2008). Critical regulation of TGF-b signaling by HSP90.  Proc Natl Acad Sci USA, 105: 9244-9249. PMID: 18591668

Wrighton KH, Lin X, Yu P, and Feng X-H (2009). TGFb stimulates Smad1 phosphorylation independently of BMP receptors. J Biol Chem, 284:9755-9763. PMID: 19224917

Dai F, Lin X, Chang C, and Feng X-H (2009). Nuclear export of Smad2 and Smad3 by RanBP3 facilitates termination of TGFb signaling. Dev Cell, 16:345-357. PMID: 19289081

 

E. RESEARCH SUPPORT

R01 GM063773                       PI: X.-H. Feng, Ph.D.                    08/01/2001-06/30/2011                 1.2 ca. mo.

NIH/NIGMS                             

"Regulation of TGF-beta receptor signaling by Hsp90"               

The main goal of the project is to elucidate the molecular mechanisms by which HSP90 regulates TGF-beta receptor signaling.

Role: PI

 

R01 CA108454                       PI: X.-H. Feng, Ph.D.                    07/01/2004-06/30/2011                 1.2 ca. mo.

NIH/NCI

"Mechanism for TGF-beta signaling termination”

The main goal of the project is to elucidate the molecular mechanisms and physiological consequences of the regulation of Smad4/DPC4 by ubiquitin/proteasome and SUMOylation pathways in normal and cancer cells.

Role: PI

 

R01 AR053591                       PI: X.-H. Feng, Ph.D.                    08/01/2008-07/31/2013                 1.8 ca. mo.

NIH/NIAMS                                                                                      

“Roles of Smad1 dephosphorylation in osteoblast differentiation”

The main goal of the project is to identify Smad1 phosphatases and characterize their roles in BMP-induced osteoblast differentiation.

Role: PI

 

BC074895                               PI: X.-H. Feng, Ph.D.                    06/01/2008-05/31/2011                 1.2 ca. mo.

DoD-BCRP

“Regulation of PPM1A-mediated Smad dephosphorylation in breast cancer”

The main goal of the project is to investigate the physiological consequences of PPM1A-mediated Smad dephosphorylation in breast cancer.

Role: PI

 

P50 HL083794                        PD/PI: Dianna Milewicz                05/01/2006-04/30/2011                 1.2 ca. mo.

NIH/NHLBI                                                                                    

TGF-b signaling in thoracic aortic aneurysms and dissections (Subcontract of Project 1 of SCCOR)

The main goal of the project is to examine the TGF-b signaling events in TAAD.

Role: Subcontract PI

 

RC2AR059010                        PD: Chen Dong                            09/01/2009-08/31/2011                 1.2 ca. mo.

NIH/NIAMS                                                                                    

“Transcriptomic and epigenomic basis of helper T cell specification and plasticity”

The main goal of the project is to to perform large-scale, genome-wide transcriptome and epigenome analysis of Treg, Th17 and Tfh cells to determine the direct functions of key transcription factors and their likely agonistic and antagonistic interaction.

Role: PI (This is a RC2 grant with multiple PIs)